28 februari 2021
| uur | terrein | thuisploeg | bezoeker | |
|---|---|---|---|---|
| A | ||||
| W22A1 | 09:15 | Zwevezele | Keuken Roberdo | DDT Veldegem |
| W22A2 | 09:30 | Wingene | Blue Stars | VK Denys |
| W22A3 | 09:00 | Jonkershove | RW Nieuwe Stee | FC Cera |
| W22A4 | 09:30 | Handzame | FC De Geite | Devolder Sport |
| W22A5 | 08:45 | Rumbeke | Geel Zwart Tube | FC Ter Mote |
| W22A6 | 08:45 | Ingelmunster | White-Red | Wivo Sport |
| W22A7 | BYE | De Krisnaldo's | ||
| B | ||||
| W22B1 | 09:30 | Lichtervelde | Jong CD&V W-Dress | VPA Sleihage |
| W22B2 | 10:10 | Kerelsplein | Re-Act | FC 't Kloefke |
| W22B3 | 09:30 | Koekelare | Dakwerken Maekelberg | Sportief Izegem |
| W22B4 | 09:00 | Cringhene | K2 United | FC Metteboys |
| W22B5 | 09:15 | Pittem | STM Sjotters | FC Transilvania |
| W22B6 | 09:15 | Koolskamp | AC 't Rozeke | KWB Don Bosco |
| W22B7 | BYE | VC Rollegem-Kapelle | ||
| C | ||||
| W22C1 | 09:00 | Kachtem | VK Kachtem | FC De Koolmijn |
| W22C2 | 09:30 | Merkem | Merkem Sport | FC 't Schaek |
| W22C3 | 09:00 | Cera | FC Boomerang | VK Zwarte Gat |
| W22C4 | 08:45 | Cera | FC Allemanshotters | FC 't Lepelke |
| W22C5 | 09:30 | Kortemark | SV Werken | Transvaal |
| W22C6 | 08:45 | Kerelsplein | FC Aditco | Scoutaboe |
| W22C7 | 09:15 | Woumen | SV Woumen | Turbo's |