21 februari 2021
| uur | terrein | thuisploeg | bezoeker | |
|---|---|---|---|---|
| A | ||||
| W21A1 | 09:15 | Veldegem | DDT Veldegem | Wivo Sport |
| W21A2 | 09:15 | Zwevezele | Keuken Roberdo | FC Cera |
| W21A3 | 09:00 | Jonkershove | RW Nieuwe Stee | FC Ter Mote |
| W21A4 | 09:30 | Handzame | FC De Geite | Blue Stars |
| W21A5 | 08:45 | Rumbeke | Geel Zwart Tube | De Krisnaldo's |
| W21A6 | 08:45 | Ingelmunster | White-Red | Devolder Sport |
| W21A7 | BYE | VK Denys | ||
| B | ||||
| W21B1 | 09:15 | Wevelgem | FC Metteboys | STM Sjotters |
| W21B2 | 08:45 | Cringhene | VPA Sleihage | VC Rollegem-Kapelle |
| W21B3 | 08:45 | Kerelsplein | Re-Act | Jong CD&V W-Dress |
| W21B4 | 10:10 | Kerelsplein | FC Transilvania | AC 't Rozeke |
| W21B5 | 09:00 | Emelgem | Sportief Izegem | K2 United |
| W21B6 | 08:45 | Staden | FC 't Kloefke | Dakwerken Maekelberg |
| W21B7 | BYE | KWB Don Bosco | ||
| C | ||||
| W21C1 | 08:45 | Cera | FC Allemanshotters | SV Werken |
| W21C2 | 09:15 | Poelkapelle | FC De Koolmijn | SV Woumen |
| W21C3 | 10:10 | Kortemark | Scoutaboe | Turbo's |
| W21C4 | 09:00 | Madonna | Transvaal | FC Aditco |
| W21C5 | 09:30 | Dominiek Savio | VK Zwarte Gat | FC 't Lepelke |
| W21C6 | 08:45 | Kortemark | FC 't Schaek | FC Boomerang |
| W21C7 | 09:30 | Merkem | Merkem Sport | VK Kachtem |