20 februari 2022
| uur | terrein | thuisploeg | bezoeker | ||||
|---|---|---|---|---|---|---|---|
| reeks A | |||||||
| W21A1 | 08:45 | Rumbeke | Geel Zwart Tube | Blue Stars | 6 | - | 2 |
| W21A2 | 09:15 | Cera | FC Cera | RW Nieuwe Stee | 2 | - | 2 |
| W21A3 | FORFAIT | Ruddervoorde | FC Ter Mote | White-Red (ff) | 5 | - | 0 |
| W21A4 | 08:45 | St. Eloois-Winkel | Wivo Sport | K2 United | 1 | - | 1 |
| W21A5 | 08:45 | Ingelmunster | Devolder Sport | FC De Geite | 1 | - | 4 |
| W21A6 | 09:15 | Veldegem | DDT Veldegem | De Krisnaldo's | 0 | - | 3 |
| W21A7 | 09:15 | Zwevezele | Keuken Roberdo | VK Denys | 2 | - | 1 |
| reeks B | |||||||
| W21B1 | 09:00 | Wijnendale | KWB Don Bosco | STM Sjotters | 4 | - | 3 |
| W21B2 | FORFAIT | Lichtervelde | Jong CD&V W-Dress (ff) | Sportief Izegem | 0 | - | 5 |
| W21B3 | 09:15 | Wevelgem | FC Metteboys | SV Werken | 2 | - | 0 |
| W21B4 | 10:20 | Kerelsplein | FC Transilvania | AC 't Rozeke | 1 | - | 2 |
| W21B5 | 08:45 | Kerelsplein | Re-Act | Transvaal | 2 | - | 3 |
| W21B6 | 08:45 | Staden | FC 't Kloefke | Dakwerken Maekelberg | 0 | - | 2 |
| W21B7 | 08:45 | Cringhene | VPA Sleihage | VC Rollegem-Kapelle | 2 | - | 3 |
| reeks C | |||||||
| W21C1 | 09:30 | Merkem | Merkem Sport | VK Zwarte Gat | 3 | - | 3 |
| W21C2 | 08:45 | Cera | FC Boomerang | FC De Koolmijn | 1 | - | 1 |
| W21C3 | 08:45 | Moorslede | FC 't Lepelke | FC 't Schaek | 2 | - | 2 |
| W21C4 | FORFAIT | Woumen | SV Woumen | FC Aditco (ff) | 5 | - | 0 |
| W21C5 | 09:30 | Kortemark | Scoutaboe | Turbo's | 3 | - | 2 |
| W21C6 | 09:15 | Dominiek Savio | FC No Surrender | FC Allemanshotters | 2 | - | 4 |
| W21C7 | 10:20 | Rumbeke | FC 't Motje | VK Kachtem | 0 | - | 4 |