20 februari 2022
| uur | terrein | thuisploeg | bezoeker | |
|---|---|---|---|---|
| reeks A | ||||
| W21A1 | 08:45 | De Ark | Geel Zwart Tube | Blue Stars |
| W21A2 | 09:15 | Cera | FC Cera | RW Nieuwe Stee |
| W21A3 | 09:15 | Ruddervoorde | FC Ter Mote | White-Red |
| W21A4 | 08:45 | St. Eloois-Winkel | Wivo Sport | K2 United |
| W21A5 | 08:45 | Ingelmunster | Devolder Sport | FC De Geite |
| W21A6 | 09:15 | Veldegem | DDT Veldegem | De Krisnaldo's |
| W21A7 | 09:15 | Zwevezele | Keuken Roberdo | VK Denys |
| reeks B | ||||
| W21B1 | 09:00 | Wijnendale | KWB Don Bosco | STM Sjotters |
| W21B2 | 09:30 | Lichtervelde | Jong CD&V W-Dress | Sportief Izegem |
| W21B3 | 09:15 | Wevelgem | FC Metteboys | SV Werken |
| W21B4 | 09:15 | Koolskamp | AC 't Rozeke | FC Transilvania |
| W21B5 | 08:45 | Kerelsplein | Re-Act | Transvaal |
| W21B6 | 08:45 | Staden | FC 't Kloefke | Dakwerken Maekelberg |
| W21B7 | 08:45 | Cringhene | VPA Sleihage | VC Rollegem-Kapelle |
| reeks C | ||||
| W21C1 | 09:30 | Merkem | Merkem Sport | VK Zwarte Gat |
| W21C2 | 08:45 | Cera | FC Boomerang | FC De Koolmijn |
| W21C3 | 08:45 | Moorslede | FC 't Lepelke | FC 't Schaek |
| W21C4 | 09:15 | Woumen | SV Woumen | FC Aditco |
| W21C5 | 09:30 | Kortemark | Scoutaboe | Turbo's |
| W21C6 | 09:15 | Dominiek Savio | FC No Surrender | FC Allemanshotters |
| W21C7 | 10:00 | Rumbeke | FC 't Motje | VK Kachtem |