10 januari 2021
| uur | terrein | thuisploeg | bezoeker | |
|---|---|---|---|---|
| A | ||||
| W16A1 | 09:15 | Veldegem | DDT Veldegem | Blue Stars |
| W16A2 | 09:15 | Cera | FC Cera | De Krisnaldo's |
| W16A3 | 08:45 | St. Eloois-Winkel | Wivo Sport | Devolder Sport |
| W16A4 | 09:15 | Zwevezele | Keuken Roberdo | FC Ter Mote |
| W16A5 | 08:45 | Rumbeke | Geel Zwart Tube | FC De Geite |
| W16A6 | 09:30 | Lichtervelde | VK Denys | RW Nieuwe Stee |
| W16A7 | BYE | White-Red | ||
| B | ||||
| W16B1 | 08:45 | Cringhene | VPA Sleihage | FC 't Kloefke |
| W16B2 | 08:45 | Ledegem | VC Rollegem-Kapelle | Sportief Izegem |
| W16B3 | 09:00 | Wijnendale | KWB Don Bosco | FC Metteboys |
| W16B4 | 10:10 | Kerelsplein | FC Transilvania | Jong CD&V W-Dress |
| W16B5 | 09:15 | Pittem | STM Sjotters | K2 United |
| W16B6 | 09:15 | Koolskamp | AC 't Rozeke | Dakwerken Maekelberg |
| W16B7 | BYE | Re-Act | ||
| C | ||||
| W16C1 | 09:15 | Poelkapelle | FC De Koolmijn | FC 't Schaek |
| W16C2 | 09:15 | Woumen | SV Woumen | VK Zwarte Gat |
| W16C3 | 10:10 | Kortemark | Scoutaboe | FC Allemanshotters |
| W16C4 | 09:00 | Kachtem | VK Kachtem | Transvaal |
| W16C5 | 08:45 | Kortemark | SV Werken | FC 't Lepelke |
| W16C6 | 08:45 | Kerelsplein | FC Aditco | FC Boomerang |
| W16C7 | 08:45 | Cera | Turbo's | Merkem Sport |