16 januari 2022
| uur | terrein | thuisploeg | bezoeker | |
|---|---|---|---|---|
| reeks A | ||||
| W16A1 | 09:00 | Jonkershove | RW Nieuwe Stee | De Krisnaldo's |
| W16A2 | 09:15 | Cera | FC Cera | Devolder Sport |
| W16A3 | 09:15 | Ruddervoorde | FC Ter Mote | Geel Zwart Tube |
| W16A4 | 08:45 | St. Eloois-Winkel | Wivo Sport | Keuken Roberdo |
| W16A5 | 09:30 | Wingene | Blue Stars | FC De Geite |
| W16A6 | 09:00 | Cringhene | K2 United | DDT Veldegem |
| W16A7 | 08:45 | Ingelmunster | White-Red | VK Denys |
| reeks B | ||||
| W16B1 | 09:00 | Emelgem | Sportief Izegem | FC 't Kloefke |
| W16B2 | 09:30 | Lichtervelde | Jong CD&V W-Dress | Re-Act |
| W16B3 | 09:15 | Wevelgem | FC Metteboys | KWB Don Bosco |
| W16B4 | 08:45 | Ledegem | VC Rollegem-Kapelle | AC 't Rozeke |
| W16B5 | 09:15 | Pittem | STM Sjotters | Transvaal |
| W16B6 | 08:45 | De Ark | FC Transilvania | Dakwerken Maekelberg |
| W16B7 | 10:20 | Kortemark | SV Werken | VPA Sleihage |
| reeks C | ||||
| W16C1 | 09:15 | Poelkapelle | FC De Koolmijn | FC Allemanshotters |
| W16C2 | 08:45 | Cera | FC Boomerang | Scoutaboe |
| W16C3 | 08:45 | Moorslede | FC 't Lepelke | Merkem Sport |
| W16C4 | 09:15 | Woumen | SV Woumen | VK Kachtem |
| W16C5 | 09:30 | Dominiek Savio | VK Zwarte Gat | Turbo's |
| W16C6 | 08:45 | Kerelsplein | FC Aditco | FC No Surrender |
| W16C7 | 08:45 | Kortemark | FC 't Schaek | FC 't Motje |