26 september 2021
| uur | terrein | thuisploeg | bezoeker | ||||
|---|---|---|---|---|---|---|---|
| reeks A | |||||||
| W4A1 | 09:00 | Jonkershove | RW Nieuwe Stee | Devolder Sport | 1 | - | 3 |
| W4A2 | 09:15 | Cera | FC Cera | Geel Zwart Tube | 1 | - | 4 |
| W4A3 | 09:15 | Ruddervoorde | FC Ter Mote | Wivo Sport | 2 | - | 1 |
| W4A4 | 09:15 | Zwevezele | Keuken Roberdo | FC De Geite | 2 | - | 1 |
| W4A5 | 09:30 | Forfait | Blue Stars | DDT Veldegem (FF) | 5 | - | 0 |
| W4A6 | 09:00 | Cringhene | K2 United | VK Denys | 1 | - | 3 |
| W4A7 | 08:45 | Ingelmunster | White-Red | De Krisnaldo's | 5 | - | 0 |
| reeks B | |||||||
| W4B1 | 09:00 | Emelgem | Sportief Izegem | Re-Act | 1 | - | 3 |
| W4B2 | 09:30 | Forfait | Jong CD&V W-Dress (FF) | KWB Don Bosco | 0 | - | 5 |
| W4B3 | 09:15 | Wevelgem | FC Metteboys | AC 't Rozeke | 1 | - | 8 |
| W4B4 | 08:45 | Ledegem | VC Rollegem-Kapelle | Transvaal | 0 | - | 5 |
| W4B5 | 09:15 | Pittem | STM Sjotters | Dakwerken Maekelberg | 2 | - | 1 |
| W4B6 | 08:45 | De Ark | FC Transilvania | VPA Sleihage | 12 | - | 0 |
| W4B7 | 10:20 | Kortemark | SV Werken | FC 't Kloefke | 0 | - | 2 |
| reeks C | |||||||
| W4C1 | 09:15 | Poelkapelle | FC De Koolmijn | Scoutaboe | 3 | - | 1 |
| W4C2 | 08:45 | Cera | FC Boomerang | Merkem Sport | 4 | - | 2 |
| W4C3 | 08:45 | Moorslede | FC 't Lepelke | SV Woumen | 3 | - | 4 |
| W4C4 | 09:00 | Kachtem | VK Kachtem | Turbo's | 4 | - | 1 |
| W4C5 | 09:30 | Dominiek Savio | VK Zwarte Gat | FC No Surrender | 9 | - | 0 |
| W4C6 | 10:20 | De Ark | FC Aditco | FC 't Motje | 0 | - | 9 |
| W4C7 | 08:45 | Kortemark | FC 't Schaek | FC Allemanshotters | 3 | - | 1 |