5 september 2021
| uur | terrein | thuisploeg | bezoeker | ||||
| reeks A | |||||||
| W1A1 | 08:45 | De Ark | Geel Zwart Tube | Keuken Roberdo | 4 | - | 0 |
| W1A2 | 08:45 | Ingelmunster | Devolder Sport | Wivo Sport | 3 | - | 1 |
| W1A3 | 09:15 | Cera | De Krisnaldo's | FC Ter Mote | 1 | - | 1 |
| W1A4 | 09:30 | Lichtervelde | VK Denys | FC Cera | 3 | - | 1 |
| W1A5 | 09:15 | Veldegem | DDT Veldegem | RW Nieuwe Stee | 2 | - | 5 |
| W1A6 | 09:30 | Handzame | FC De Geite | White-Red | 2 | - | 2 |
| W1A7 | 09:30 | Wingene | Blue Stars | K2 United | 2 | - | 2 |
| reeks B | |||||||
| W1B1 | 09:00 | Wijnendale | KWB Don Bosco | VC Rollegem-Kapelle | 3 | - | 2 |
| W1B2 | 10:20 | De Ark | Re-Act | AC 't Rozeke | 2 | - | 4 |
| W1B3 | 08:45 | Staden | FC 't Kloefke | FC Metteboys | 3 | - | 0 |
| W1B4 | 08:45 | Cringhene | VPA Sleihage | Jong CD&V W-Dress | 1 | - | 3 |
| W1B5 | 09:30 | Koekelare | Dakwerken Maekelberg | Sportief Izegem | 3 | - | 0 |
| W1B6 | 09:00 | Madonna | Transvaal | SV Werken | 5 | - | 1 |
| W1B7 | 09:15 | Pittem | STM Sjotters | FC Transilvania | 0 | - | 9 |
| reeks C | |||||||
| W1C1 | 09:30 | Merkem | Merkem Sport | VK Kachtem | 0 | - | 7 |
| W1C2 | 09:30 | Kortemark | Scoutaboe | SV Woumen | 0 | - | 4 |
| W1C3 | 08:45 | Cera | FC Allemanshotters | FC 't Lepelke | 1 | - | 1 |
| W1C4 | 10:00 | Rumbeke | FC 't Motje | FC Boomerang | 9 | - | 2 |
| W1C5 | 09:15 | Poelkapelle | FC De Koolmijn | FC No Surrender | 8 | - | 0 |
| W1C6 | 10:20 | Cera | Turbo's | FC 't Schaek | 3 | - | 5 |
| W1C7 | 09:30 | Dominiek Savio | VK Zwarte Gat | FC Aditco | 1 | - | 1 |