5 december 2021
| uur | terrein | thuisploeg | bezoeker | |
|---|---|---|---|---|
| reeks A | ||||
| W12A1 | 08:45 | Ingelmunster | Devolder Sport | Keuken Roberdo |
| W12A2 | 09:15 | Cera | De Krisnaldo's | Geel Zwart Tube |
| W12A3 | 09:30 | Lichtervelde | VK Denys | Wivo Sport |
| W12A4 | 09:15 | Ruddervoorde | FC Ter Mote | DDT Veldegem |
| W12A5 | 09:30 | Handzame | FC De Geite | FC Cera |
| W12A6 | 09:30 | Wingene | Blue Stars | RW Nieuwe Stee |
| W12A7 | 09:00 | Cringhene | K2 United | White-Red |
| reeks B | ||||
| W12B1 | 09:15 | Ledegem | VC Rollegem-Kapelle | Re-Act |
| W12B2 | 08:45 | Staden | FC 't Kloefke | KWB Don Bosco |
| W12B3 | 09:15 | Koolskamp | AC 't Rozeke | VPA Sleihage |
| W12B4 | 09:30 | Koekelare | Dakwerken Maekelberg | FC Metteboys |
| W12B5 | 09:00 | Madonna | Transvaal | Jong CD&V W-Dress |
| W12B6 | 09:15 | Pittem | STM Sjotters | Sportief Izegem |
| W12B7 | 10:20 | De Ark | FC Transilvania | SV Werken |
| reeks C | ||||
| W12C1 | 09:30 | Kortemark | Scoutaboe | VK Kachtem |
| W12C2 | 10:20 | Cera | FC Allemanshotters | Merkem Sport |
| W12C3 | 10:00 | Rumbeke | FC 't Motje | SV Woumen |
| W12C4 | 09:15 | Dominiek Savio | FC No Surrender | FC 't Lepelke |
| W12C5 | 08:45 | Cera | Turbo's | FC Boomerang |
| W12C6 | 09:15 | Poelkapelle | FC De Koolmijn | VK Zwarte Gat |
| W12C7 | 08:45 | De Ark | FC Aditco | FC 't Schaek |