21 november 2021
| uur | terrein | thuisploeg | bezoeker | |
|---|---|---|---|---|
| reeks A | ||||
| W10A1 | 09:15 | Zwevezele | Keuken Roberdo | De Krisnaldo's |
| W10A2 | 09:30 | Lichtervelde | VK Denys | Devolder Sport |
| W10A3 | 09:15 | Veldegem | DDT Veldegem | Geel Zwart Tube |
| W10A4 | 08:45 | St. Eloois-Winkel | Wivo Sport | FC De Geite |
| W10A5 | 09:30 | Wingene | Blue Stars | FC Ter Mote |
| W10A6 | 09:00 | Cringhene | K2 United | FC Cera |
| W10A7 | 08:45 | Ingelmunster | White-Red | RW Nieuwe Stee |
| reeks B | ||||
| W10B1 | 08:45 | Ledegem | VC Rollegem-Kapelle | FC 't Kloefke |
| W10B2 | 10:20 | De Ark | Re-Act | VPA Sleihage |
| W10B3 | 09:30 | Koekelare | Dakwerken Maekelberg | KWB Don Bosco |
| W10B4 | 09:00 | Madonna | Transvaal | AC 't Rozeke |
| W10B5 | 09:15 | Pittem | STM Sjotters | FC Metteboys |
| W10B6 | 08:45 | De Ark | FC Transilvania | Jong CD&V W-Dress |
| W10B7 | 10:20 | Kortemark | SV Werken | Sportief Izegem |
| reeks C | ||||
| W10C1 | 09:00 | Kachtem | VK Kachtem | FC Allemanshotters |
| W10C2 | 10:00 | Rumbeke | FC 't Motje | Scoutaboe |
| W10C3 | 09:15 | Dominiek Savio | FC No Surrender | Merkem Sport |
| W10C4 | 08:45 | Cera | Turbo's | SV Woumen |
| W10C5 | 08:45 | Moorslede | FC 't Lepelke | VK Zwarte Gat |
| W10C6 | 10:20 | Cera | FC Boomerang | FC Aditco |
| W10C7 | 08:45 | Kortemark | FC 't Schaek | FC De Koolmijn |