10 oktober 2021
| uur | terrein | thuisploeg | bezoeker | ||||
|---|---|---|---|---|---|---|---|
| reeks A | |||||||
| W5A1 | 09:00 | Jonkershove | RW Nieuwe Stee | Wivo Sport | 4 | - | 7 |
| W5A2 | 09:15 | Cera | FC Cera | FC Ter Mote | 0 | - | 7 |
| W5A3 | 09:15 | Zwevezele | Keuken Roberdo | DDT Veldegem | 4 | - | 4 |
| W5A4 | 09:30 | Handzame | FC De Geite | VK Denys | 1 | - | 0 |
| W5A5 | 09:30 | Wingene | Blue Stars | De Krisnaldo's | 2 | - | 3 |
| W5A6 | 09:00 | Cringhene | K2 United | Devolder Sport | 4 | - | 1 |
| W5A7 | 08:45 | Ingelmunster | White-Red | Geel Zwart Tube | 3 | - | 1 |
| reeks B | |||||||
| W5B1 | 09:00 | Emelgem | Sportief Izegem | AC 't Rozeke | 0 | - | 1 |
| W5B2 | 09:30 | Lichtervelde | Jong CD&V W-Dress | FC Metteboys | 1 | - | 6 |
| W5B3 | 08:45 | Ledegem | VC Rollegem-Kapelle | Dakwerken Maekelberg | 2 | - | 2 |
| W5B4 | 09:00 | Madonna | Transvaal | VPA Sleihage | 5 | - | 1 |
| W5B5 | 09:15 | Pittem | STM Sjotters | FC 't Kloefke | 1 | - | 2 |
| W5B6 | 10:20 | De Ark | FC Transilvania | Re-Act | 2 | - | 2 |
| W5B7 | 10:20 | Kortemark | SV Werken | KWB Don Bosco | 1 | - | 6 |
| reeks C | |||||||
| W5C1 | 09:15 | Poelkapelle | FC De Koolmijn | SV Woumen | 0 | - | 1 |
| W5C2 | 08:45 | Moorslede | FC 't Lepelke | FC Boomerang | 1 | - | 2 |
| W5C3 | 09:00 | Kachtem | VK Kachtem | FC No Surrender | 11 | - | 1 |
| W5C4 | 08:45 | Cera | Turbo's | FC 't Motje | 2 | - | 2 |
| W5C5 | 09:30 | Dominiek Savio | VK Zwarte Gat | FC Allemanshotters | 5 | - | 1 |
| W5C6 | 08:45 | De Ark | FC Aditco | Scoutaboe | 0 | - | 3 |
| W5C7 | 08:45 | Kortemark | FC 't Schaek | Merkem Sport | 1 | - | 2 |