4 september 2022
| uur | terrein | thuisploeg | bezoeker | ||||
| REEKS A | |||||||
| W1A1 | 9:00 | Cringhene | K2 United | Keukens Roberdo | 1 | - | 2 |
| W1A2 | 9:00 | Jonkershove | RW Nieuwe Stee | Geel Zwart Tube | 0 | - | 0 |
| W1A3 | 14/9 19:30 | Handzame | FC De Geite | FC Ter Mote | 0 | - | 2 |
| W1A4 | 8:45 | St. Eloois-Winkel | Wivo Sport | AC 't Rozeke | 3 | - | 0 |
| W1A5 | 9:15 | Veldegem | DDT Veldegem | Blue Stars | 3 | - | 2 |
| W1A6 | 9:30 | Lichtervelde | VK Denys | FC Transilvania | 1 | - | 1 |
| W1A7 | 8:45 | Ingelmunster | Devolder Sport | De Krisnaldo's | 5 | - | 0 |
| REEKS B | |||||||
| W1B1 | 9:00 | Wijnendale | KWB Don Bosco | Sportief Izegem | 3 | - | 1 |
| W1B2 | 9:15 | De Ruiter | FC 't Hoekske | FC Metteboys | 1 | - | 3 |
| W1B3 | 9:15 | Pittem | STM Sjotters | VC Rollegem-Kapelle | 1 | - | 0 |
| W1B4 | 9:00 | Koekelare | Dakwerken Maekelberg | Transvaal | 1 | - | 1 |
| W1B5 | 10:20 | Kortemark | SV Werken | FC 't Kloefke | 0 | - | 3 |
| W1B6 | 9:00 | Bosmolens | VK Kachtem | SV Woumen | 3 | - | 2 |
| W1B7 | BYE | VPA Sleihage | - | ||||
| REEKS C | |||||||
| W1C1 | 8:45 | Kerelsplein | FC Aditco | Merkem Sport | 5 | - | 0 |
| W1C2 | 10:20 | Kerelsplein | FC Sherry's Pub | FC 't Motje | 0 | - | 5 |
| W1C3 | 9:15 | Dominiek Savio | FC No Surrender | Scoutaboe | 0 | - | 8 |
| W1C4 | 8:45 | Moorslede | FC QVH | FC Allemanshotters | 2 | - | 1 |
| W1C5 | 8:45 | Kortemark | FC 't Schaek | VK Zwarte Gat | 2 | - | 1 |
| W1C6 | BYE | Turbo's | - | ||||
| W1C7 | 9:15 | Poelkapelle | FC De Koolmijn | B-Volted United | 0 | - | 2 |